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Two-locus linkage analysis applied to putative quantitative trait loci for lipoprotein(a) levels
Marian Beekman1, Bastiaan T Heijmans, Nicholas G Martin
1Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. M.Beekman@lumc.nl.
Abstract:
Plasma levels of lipoprotein(a) - Lp(a) - are associated with cardiovascular risk (Danesh et al., 2000) and were long believed to be influenced by the LPA locus on chromosome 6q27 only. However, a recent report of Broeckel et al. (2002) suggested the presence of a second quantitative trait locus on chromosome 1 influencing Lp(a) levels. Using a two-locus model, we found no evidence for an additional Lp(a) locus on chromosome 1 in a linkage study among 483 dizygotic twin pairs.