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Planar microcoil-based microfluidic NMR probes.

C Massin1, F Vincent, A Homsy

  • 1Institute of Microelectronics and Microsystems, EPFL-Swiss Federal Institute of Technology Lausanne, BM 3.108, Lausanne CH-1015, Switzerland. charles.massin@epfl.ch

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|September 27, 2003
PubMed
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Researchers developed microfluidic NMR probes for small sample volumes, demonstrating sensitivity for on-chip spectroscopy. They identified magnetic field distortions as a key limitation for future high-resolution applications.

Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Nuclear Magnetic Resonance (NMR) Spectroscopy

Background:

  • Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful analytical technique.
  • miniaturization of NMR probes is crucial for analyzing small sample volumes.
  • Microfluidic systems offer precise control over sample handling.

Purpose of the Study:

  • To fabricate and test microfabricated NMR probes with integrated microfluidic channels.
  • To demonstrate the feasibility of on-chip NMR spectroscopy for small volumes.
  • To investigate the relationship between probe design and performance.

Main Methods:

  • Fabrication of microfluidic NMR probes using electroplated planar microcoils on glass substrates.
  • Acquisition of 1H NMR spectra at 300 MHz using probes with volumes of 30, 120, and 470 nL.

Related Experiment Videos

  • Development and application of models to predict signal-to-noise ratio and spectral resolution.

    • Main Results:

    • Successful acquisition of 1H NMR spectra from microgram quantities of sucrose, proving the concept of on-chip NMR.
    • Experimental demonstration of increased mass-sensitivity with reduced coil diameter in planar microcoils.
    • Identification of probe-induced static magnetic field distortions as the primary limitation for high-resolution NMR.

    Conclusions:

    • Microfabricated microfluidic NMR probes are viable for on-chip spectroscopy.
    • Probe design, particularly coil diameter, significantly impacts mass-sensitivity.
    • Minimizing static magnetic field distortions is critical for advancing high-resolution microfluidic NMR applications.