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Published on: February 17, 2019
Surgical management of retroperitoneal sarcomas associated with external and intraoperative electron beam
J Y Bobin1, T Al-Lawati, L E Granero
1Department of Surgical Oncology, Centre Hospitalier Lyon Sud, 69495 Pierre Benite Cedex, France. service.bobin@chu-lyon.fr
Aims:
To report outcomes of adults with retroperitoneal sarcoma (RS) treated by surgery, external beam radiotherapy (EBRT) and intraoperative electron beam radiotherapy (IORT).
Methods:
From July 1988 to February 2001; 24 patients with primary and recurrent RS were diagnosed and treated. The median dose and energy of IORT delivered was 15 Gy/9meV. EBRT dose varies between 45-50 Gy.
Results:
There were five primary and 19 recurrent tumours. One primary and five recurrent tumours underwent R0 resection. There were 12 liposarcomas and 19 grade I tumours; 13 patients developed local recurrence and three developed distant metastases.Twenty-two patients received IORT associated with EBRT: 11 developed recurrences. Six patients developed Neurotoxicity (4 grade II and 2 grade III). Disease free survival and overall survival at 5 years was 28 and 56% respectively.
Conclusions:
EBRT with IORT treatment is a promising technique for local control. Lower recurrence rates are associated with radical (R0) surgical procedures.
