Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Telomere maintenance and disease.

Judy M Y Wong1, Kathleen Collins

  • 1Department of Molecular and Cell Biology, University of California at Berkeley, 401 Barker Hall, Berkeley, CA 94720-3204, USA.

Lancet (London, England)
|September 27, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers.

Signal transduction and targeted therapy·2026
Same author

Lineage-specific evolution, structural diversity, and activity of R2 retrotransposons in animals.

Genome biology·2026
Same author

Effects of a Mandatory Orthopaedic Surgery Rotation on Medical Student Perceptions of the Field.

Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews·2026
Same author

Celebrating a decade of JCI Insight - reflections from a former Editor in Chief.

JCI insight·2026
Same author

Different DNA repair pathways support intact or truncated insertions by R2 retrotransposon protein.

Science (New York, N.Y.)·2025
Same author

Endosome transcriptomics reveal trafficking of Cajal bodies into multivesicular bodies.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
See all related articles

Telomerase, an enzyme for telomeric DNA synthesis, is crucial for cell proliferation. Its activation is vital in cancer and normal cells, while insufficient telomerase can lead to disease and premature telomere shortening.

Area of Science:

  • Cell biology
  • Molecular biology
  • Genetics

Background:

  • Cell proliferation is regulated by telomerase, an enzyme critical for telomeric DNA synthesis.
  • Telomerase activation is essential for cancer progression and maintenance.
  • Emerging evidence highlights telomerase's role in normal somatic cells and disease development.

Purpose of the Study:

  • To review the role of telomerase in normal somatic cells.
  • To examine evidence linking telomerase activation to proliferative deficiencies.
  • To discuss the therapeutic potential of telomerase activation in gene therapy.

Main Methods:

  • Literature review of studies on telomerase, cancer, and cell culture.
  • Analysis of evidence for premature telomere attrition in hematopoietic deficiencies.

Related Experiment Videos

  • Discussion of telomere-restorative gene therapy strategies.

    • Main Results:

    • Telomerase activation is critical for both cancer and normal cell proliferation.
    • Failure to activate sufficient telomerase contributes to disease.
    • Premature telomere attrition is observed in human hematopoietic proliferative deficiencies.

    Conclusions:

    • Telomerase plays a significant role in normal somatic cell function.
    • Dysregulation of telomerase contributes to various diseases.
    • Telomere-restorative gene therapy holds promise for treating telomere-related disorders.