Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Developmental patterning in the Caenorhabditis elegans hindgut.

Stephen T Sewell1, Guojuan Zhang, Ashwin Uttam

  • 1Department of Molecular Genetics, Ohio State University, Columbus, OH 43210, USA.

Developmental Biology
|September 27, 2003
PubMed
Summary

Researchers studied gene expression in the C. elegans hindgut to understand developmental pattern formation. Findings suggest multiple factors converge to specify cell types during development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A gap-free, telomere-to-telomere genome assembly for the Caenorhabditis briggsae reference strain AF16.

G3 (Bethesda, Md.)·2026
Same author

Planar tetracoordinate carbon in boron-based cluster CB<sub>4</sub>S<sub>6</sub> stabilized by peripheral bridging sulfur atoms.

Chemical communications (Cambridge, England)·2026
Same author

A gap-free, telomere-to-telomere genome assembly for the <i>Caenorhabditis briggsae</i> reference strain AF16.

bioRxiv : the preprint server for biology·2026
Same author

Molecularly imprinted polyphenylboronic acid/carboxylated graphene-based electrochemical sensor for ultrasensitive detection of 3-monochloropropane-1,2-diol in soy sauces.

Food chemistry·2026
Same author

Coincident evolution and functional adaptation of the taxonomically restricted genes ivph-3 and gon-14 in Caenorhabditis nematodes.

Biology open·2025
Same author

Association Between Serum Lycopene Concentrations and Diabetic Kidney Disease in the Elderly With Diabetes Mellitus: A Cross-Sectional Study From the NHANES Database.

Journal of diabetes research·2025

Area of Science:

  • Developmental Biology
  • Genetics
  • Cell Biology

Background:

  • Pattern formation is crucial for coordinating cell development and differentiation within tissues.
  • Understanding how specific cell fates are established during organogenesis is a fundamental biological question.

Purpose of the Study:

  • To investigate the developmental patterning events in the C. elegans hindgut.
  • To analyze the expression patterns of key genes involved in hindgut development.
  • To determine how gene expression changes in response to developmental alterations.

Main Methods:

  • Utilized green fluorescent protein (GFP)-based reporter transgenes to visualize gene expression patterns.
  • Analyzed gene expression in wild-type and mutant C. elegans hindgut tissues.

Related Experiment Videos

  • Correlated gene expression changes with observed cellular developmental alterations.

    • Main Results:

    • Identified specific subsets of hindgut cells expressing analyzed genes, rather than uniform expression across cell types.
    • Observed alterations in gene expression in some, but not all, genes within cells exhibiting abnormal development.
    • Demonstrated that gene expression patterns do not always directly correlate with cell fate in mutant backgrounds.

    Conclusions:

    • Cell fate determination in the C. elegans hindgut is likely influenced by a combination of developmental factors.
    • Developmental information converges through complex mechanisms to specify distinct cell types.
    • The study provides insights into the regulatory networks governing organogenesis and cell differentiation.