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Induced sputum inflammatory mediator concentrations in chronic cough
Surinder S Birring1, Debbie Parker, Christopher E Brightling
1Department of Respiratory Medicine, Institute for Lung Health, Glenfield Hospital, Leicester, United Kingdom. sb134@le.ac.uk
American Journal of Respiratory and Critical Care Medicine
|September 27, 2003
Summary
Chronic cough involves airway inflammation and mediator release. This study found higher histamine and prostaglandin levels in various chronic cough conditions, suggesting shared underlying mechanisms.
Area of Science:
- Respiratory Medicine
- Immunology
- Clinical Investigation
Background:
- Chronic cough is linked to airway inflammation and mediator release.
- The precise mechanisms driving different chronic cough types require further elucidation.
Purpose of the Study:
- To investigate the concentrations of inflammatory and tussive mediators in induced sputum of patients with various chronic cough conditions.
- To explore potential similarities in cough mechanisms across different etiologies.
Main Methods:
- Enzyme immunoassay was used to measure histamine, cysteinyl-leukotrienes, prostanoids (prostaglandin D2, prostaglandin E2), and interleukin-8.
- Induced sputum supernatants were analyzed from patients with cough variant asthma/eosinophilic bronchitis, nonasthmatic chronic cough, idiopathic chronic cough, and healthy controls.
Main Results:
- Significantly elevated sputum histamine concentrations were observed in idiopathic chronic cough and cough variant asthma/eosinophilic bronchitis compared to controls.
- Prostaglandin D2 and prostaglandin E2 levels were significantly higher in all chronic cough groups versus healthy subjects.
Conclusions:
- Findings support the role of inflammatory and tussive mediator release in chronic cough pathogenesis.
- Similarities in cough mechanisms may exist across diverse chronic cough conditions, including asthma and idiopathic cough.