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Arterial baroreflex attenuation during and after continuous propofol infusion.
1Department of Anesthesiology, University of Kansas Medical Center, Kansas City 66160-7415.
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|November 1, 1992
Summary
Propofol impairs the baroreflex, which controls blood pressure and heart rate. This study in rabbits shows propofol reduces sympathetic nerve activity, affecting blood pressure regulation during and after infusion.
Area of Science:
- Anesthesiology
- Cardiovascular Physiology
- Autonomic Nervous System
Background:
- Propofol is a common anesthetic agent.
- Propofol can reduce arterial blood pressure.
- The baroreflex is crucial for maintaining blood pressure homeostasis.
Purpose of the Study:
- To investigate arterial baroreflex sensitivity during and after propofol infusion.
- To determine if propofol affects the sympathetic nervous system's response to blood pressure changes.
Main Methods:
- Continuous recording of mean arterial pressure (MAP), heart rate (HR), and renal sympathetic nerve activity (RSNA) in urethane-anesthetized rabbits.
- Administration of phenylephrine and sodium nitroprusside (SNP) to induce blood pressure changes.
- Evaluation of baroreflex sensitivity using sympathetic baroreflex sigmoid curves and delta RSNA/delta MAP ratios.
Main Results:
- Propofol infusion attenuated RSNA in both groups compared to control.
- Baroreflex sensitivity was reduced during propofol infusion.
- RSNA gradually returned to baseline levels after propofol discontinuation in one group.
Conclusions:
- Propofol impairs arterial baroreflex sensitivity.
- The reduction in blood pressure by propofol may be due to impaired baroreflex function.
- Baroreflex function recovers after propofol discontinuation.