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Postinfectious bronchiolitis obliterans in children: clinical and radiological profile and prognostic factors

Ebru Yalçin1, Deniz Doğru, Mithat Haliloğlu

  • 1Chest Diseases Unit, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey. ebruy@hacettepe.edu.tr

Respiration; International Review of Thoracic Diseases
|September 27, 2003
PubMed

Insights

Postinfectious bronchiolitis obliterans (BO) in children is linked to chronic airflow obstruction. This study found adenoviruses as a common cause but no clear prognostic factors for disease severity.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Postinfectious bronchiolitis obliterans (BO) is a syndrome of chronic airflow obstruction.
  • It is characterized by inflammatory changes in the small airways.

Purpose of the Study:

  • To determine the etiology of postinfectious BO in children.
  • To identify clinical and radiological features.
  • To define prognostic factors for postinfectious BO.

Main Methods:

  • Retrospective review of medical records for 20 children with postinfectious BO.
  • Follow-up period from January 1994 to August 2001.
  • Diagnosis confirmed by thoracic high-resolution computed tomography and clinical features.

Main Results:

  • Adenoviruses were the most common identified etiologic agents.
  • Cough and wheezing persisted in all patients post-infection.
  • No prognostic factors (age, gender, treatment timing, bronchiectasis, atelectasis, etiology) predicted disease severity.

Conclusions:

  • The role of anti-inflammatory agents in postinfectious BO remains controversial.
  • No prognostic factors for disease severity were identified in this cohort.
  • Close follow-up and meticulous lung care are essential to minimize complications.
Abstract

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