Related Experiment Video
Updated: Aug 30, 2026

An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
Acute respiratory failure and cerebral hemorrhage due to primary Epstein-Barr virus infection
O Gautschi1, C Berger, J Gubler
1Department of Internal Medicine, Triemli Hospital, Zürich, Switzerland.
Abstract:
Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus with worldwide distribution. Primary infection with EBV occurs early in life and typically presents as infectious mononucleosis. The usual course of the disease is benign and most patients recover uneventfully. Severe infections are reported particularly in immunocompromised patients. Mild, asymptomatic pneumonitis is reported in about 5-10% of cases of infectious mononucleosis, but severe pneumonitis with hypoxemia is very rare in immunocompetent individuals. We report a young female adolescent in whom an acute EBV infection led to severe bilateral pneumonitis, a systemic inflammatory response and intracerebral bleeding. The clinical course and results of quantitative viral DNA determinations in plasma are presented.
Related Concept Videos
Encephalitis l: Introduction
Encephalitis ll: Pathophysiology
Arboviral Encephalitis
Hemorrhagic Stroke ll: Pathophysiology
Cerebral Edema ll: Pathophysiology
Viral Meningitis
