Randomised controlled short-term intervention pilot study on rye bran bread in prostate cancer.

Area of Science:

• Oncology
• Nutrition Science
• Gastroenterology

Background:

• Prostate cancer is a significant health concern.
• Dietary interventions are being explored for cancer management.
• Rye bran is a high-fiber food with potential health benefits.

Purpose of the Study:

• To investigate the short-term effects of rye bran bread intake on prostate cancer.
• To assess changes in tumor apoptosis and relevant biomarkers.
• To evaluate the impact of rye bran on prostate-specific antigen (PSA) and hormonal levels.

Main Methods:

• A randomized controlled trial involving men with conservatively treated prostate cancer.
• Participants consumed either rye bran bread or wheat bread (control) for three weeks.
• Data collected included blood samples, prostate biopsies, and urine analysis.

Main Results:

• Rye bran intake led to a significant increase in plasma enterolactone.
• The apoptotic index in prostate tumors significantly increased in the rye group (P<0.005).
• Minor changes were observed in PSA, sex hormones, IGF-I, and the fibrinolytical system.

Conclusions:

• High intake of rye bran bread may promote apoptosis in prostate tumors.
• Rye bran shows potential as a dietary intervention for prostate cancer.
• Further research is warranted to confirm these findings and explore long-term effects.