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Related Experiment Videos

Selenium plasma levels in psoriasis.

A Donadini1, C Fiora, R Regazzini

  • 1Department of Dermatology, University of Pavia, IRCCS Policlinico S. Matteo, Italy.

Clinical and Experimental Dermatology
|May 1, 1992
PubMed
Summary
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This study investigated selenium levels in psoriasis patients, finding no significant reduction in plasma or whole blood. These findings contrast with previous research suggesting lower selenium may be linked to psoriasis.

Area of Science:

  • Dermatology
  • Nutritional Science
  • Biochemistry

Background:

  • Inflammatory diseases like psoriasis have unknown modulating factors.
  • Trace elements, specifically selenium, are hypothesized to influence inflammatory conditions.
  • Previous studies suggested reduced selenium levels in psoriasis patients.

Purpose of the Study:

  • To determine selenium concentrations in patients with psoriasis.
  • To compare selenium levels in psoriasis patients with healthy controls.
  • To investigate the role of selenium in modulating psoriasis.

Main Methods:

  • Selenium concentrations were measured in plasma and whole blood samples.
  • Data were collected from 64 patients diagnosed with psoriasis.
  • Patient values were statistically compared to those of matched healthy controls.

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Main Results:

  • No significant reduction in selenium concentrations was observed in psoriasis patients compared to controls.
  • Plasma selenium levels in patients were comparable to those in the control group.
  • Whole blood selenium levels also showed no significant difference between patients and controls.

Conclusions:

  • The study did not find evidence supporting reduced selenium levels in psoriasis.
  • Findings contradict previous reports suggesting a link between low selenium and psoriasis.
  • Further research is needed to fully understand the role of selenium in psoriasis pathogenesis.