Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Atopic dermatitis and psychological stress].

U Raap1, T Werfel, B Jaeger

  • 1Klinik und Poliklinik für Dermatologie und Venerologie, Medizinische Hochschule Hannover. mail@ulrike-raap.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete
|September 27, 2003
PubMed
Summary

Emotional stress triggers atopic dermatitis (AD) flares by altering immune responses and hormone levels. This psychoneuroimmunological link explains how stress aggravates this chronic inflammatory skin condition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differential regulation of 5-lipoxygenase and leukotriene-C4-synthase expression by IFNγ, IL-4 and IL-13 in human monocytes and macrophages from patients with atopic dermatitis.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2025
Same author

Baseline characteristics of atopic eczema patients enrolled in seven European registries united in the TREatment of ATopic eczema (TREAT) registry taskforce.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

European Guideline (EuroGuiDerm) on atopic eczema: Living update.

Journal of the European Academy of Dermatology and Venereology : JEADV·2025
Same author

Riboflavin transporter deficiency, the search for the undiagnosed: a retrospective data mining study.

Orphanet journal of rare diseases·2024
Same author

Clinical and molecular response to dupilumab treatment in pediatric atopic dermatitis: Results of the German TREATkids registry.

Allergy·2024
Same author

Infiltration analysis of eosinophils and basophils and co-expression of CD69, CD63, IL-31 and IgE in patients with bullous and non-bullous pemphigoid.

Journal of the European Academy of Dermatology and Venereology : JEADV·2023

Area of Science:

  • Immunodermatology
  • Psychoneuroimmunology
  • Endocrinology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by eczematous lesions and pruritus.
  • Triggers for AD include allergens, irritants, infections, pollutants, hormonal changes, and notably, emotional stress.
  • Emerging evidence suggests direct psychoneuroimmunological and -endocrinological pathways linking stress to AD pathophysiology.

Purpose of the Study:

  • To investigate the psychoneuroimmunological and -endocrinological mechanisms by which emotional stress influences atopic dermatitis.
  • To identify specific immunological and hormonal changes associated with stress-induced AD exacerbations.

Main Methods:

  • Observational study comparing immunological and hormonal profiles of AD patients experiencing stress versus healthy controls.

Related Experiment Videos

  • Analysis of peripheral blood eosinophil counts, T-cell subsets (CD8+/CD11b+, CLA+), cytokine levels (IFN-gamma, IL-5), and cortisol levels.

    • Main Results:

    • Psychological stress led to a transient increase in peripheral blood eosinophil count.
    • Stress increased CD8+/CD11b+ and CLA+ T-cells in AD patients.
    • AD patients under stress showed elevated IFN-gamma and IL-5 levels, and decreased cortisol levels compared to controls.

    Conclusions:

    • Emotional stress directly impacts the immune system and endocrine function in atopic dermatitis patients.
    • Stress-induced immunological changes and a potentially suppressed hypothalamic-pituitary-adrenal (HPA) axis contribute to AD aggravation.
    • These findings highlight the critical role of stress management in the comprehensive treatment of atopic dermatitis.