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Published on: March 9, 2016
No evidence for DUP25 in patients with panic disorder using a quantitative real-time PCR approach
Johannes Schumacher1, Andreas C J Otte, Tim Becker
1Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany. johannes.schumacher@uni-bonn.de
Abstract:
A duplication of chromosome 15q24-q26 (DUP25) has been reported to be associated with anxiety disorders. We tested for the presence of DUP25 in a sample of 50 patients with panic disorder and 50 controls using a quantitative real-time PCR approach. Contrary to the original finding, our results were compatible with the absence of DUP25, and no significant difference could be detected between patients and controls ( P=1.0). Thus, our study does not support the hypothesis of an involvement of DUP25 in panic disorder.
