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Updated: Aug 16, 2026
Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
[Treatment to cN0 patients with oral squamous cell carcinoma]
Feiwu Kang1, Zhenghua Wu, Xin Huang
1Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China.
Objective:
To investigate the regularity of cervical lymph-node metastasis in oral squamous cell carcinoma patients and determine the treatment principle to cN0 patients.
Methods:
1,024 oral squamous cell carcinoma cases who underwent neck dissection between 1980-2001 were investigated retrospectively.
Results:
The total rate of cervical lymph-node metastasis of oral squamous cell carcinoma was 36.62% (375/1,024), the metastasis rate of cancer in tongue, buccal, gingival, and floor of mouth was 42.82%, 31.93%, 32.76%, and 25.00%, respectively; the rate of occult metastasis was 20.94%(71/339), the incidence of occult metastasis was closely related to the location of primary lesion and T stage.
Conclusion:
The results in this study revealed that the therapy regime of the oral squamous cell carcinoma should be based on carefully clinical examination and compositive analysis on primary lesion related to size, location and cervical lymph-node.
