The role of neurotransmitters in neurite outgrowth and synapse formation

Besides a well-established role in neuronal communication in the adult central nervous system, neurotransmitters have diverse tasks in the embryonic brain, ranging from early developmental functions in morphogenesis /13/, to later functions in target selection and synapse formation /87/. For example, growth cones of developing neurons are known to release transmitters /26,36,88,110,115/ and respond to transmitters released from other neurons /35,44,59, 61,70/. Moreover, depletion of transmitters during embryonic development results in developmental deficits of the brain /21,48,84,109/, suggesting that transmitters have crucial roles as morphogens and/or neurotrophic factors. Although recently the idea of neurotransmitters being important for neural development has been challenged /99/, there is a vast amount of literature that seems to support the hypothesis that neurotransmitter release in the developing central nervous system is crucial for proper brain development. In this review we focus on the roles that neurotransmitters play in neurite outgrowth, target selection and synapse formation, with particular emphasis on the effects of the transmitters serotonin and dopamine.