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Published on: February 3, 2023
Insulin-induced iron loading in the rat brown adipose tissue: histochemical and electron-microscopic study
A Korać1, M Vereć, V Davidović
1Institute of Zoology, Faculty of Biology, Studentski trg 16, 11000 Belgrade, Yugoslavia. sankor@bf.bio.bg.ac.yu
In the present study we have reported an iron-loading in the rat brown adipose tissue (BAT) after 3-day treatment with insulin (4 IU/kg). Light microscopy showed numerous iron-positive cells (Perls' stain) mainly macrophages and brown adipocytes, while electron-microscopic examination revealed lipofuscin granules and phagosomes as iron-containing components. These results clearly indicate that iron participates in damaging of brown adipocytes.
In the present study we have reported an iron-loading in the rat brown adipose tissue (BAT) after 3-day treatment with insulin (4 IU/kg). Light microscopy showed numerous iron-positive cells (Perls' stain) mainly macrophages and brown adipocytes, while electron-microscopic examination revealed lipofuscin granules and phagosomes as iron-containing components. These results clearly indicate that iron participates in damaging of brown adipocytes.
