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A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
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Carotid intima-media thickness and coronary artery disease: an Indian perspective

Gupta Hansa1, Kartikeya Bhargava, Manish Bansal

  • 1Noninvasive Cardiology, Escorts Heart Institute and Research Centre, New Delhi, India.

Asian Cardiovascular & Thoracic Annals
|September 30, 2003
PubMed

Insights

Carotid intima-media thickness (CIMT) is a strong predictor of coronary artery disease in India. Higher CIMT is independently linked to coronary artery disease, regardless of other cardiovascular risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Diagnostic Imaging
  • Public Health

Background:

  • Coronary artery disease (CAD) poses a significant health burden in India.
  • Early detection of cardiovascular risk factors is crucial for prevention.
  • Carotid intima-media thickness (CIMT) is a non-invasive marker for atherosclerosis.

Purpose of the Study:

  • To investigate the association between CIMT and coronary artery disease (CAD) in the Indian population.
  • To determine if CIMT is an independent predictor of CAD.
  • To explore the relationship between CIMT and cardiovascular risk factors.

Main Methods:

  • High-resolution B-mode ultrasonography was used to measure CIMT.
  • 101 patients with CAD and 140 control subjects were included.
  • CIMT was assessed at three predefined sites on each carotid artery.

Main Results:

  • The maximum and average CIMT were significantly higher in the CAD group compared to controls.
  • Multivariate logistic regression identified CIMT as the sole independent predictor of CAD.
  • A significant association was observed between the count of cardiovascular risk factors and CIMT values.

Conclusions:

  • Elevated average and maximum CIMT are significantly associated with the presence of CAD in the Indian population.
  • CIMT is an independent predictor of CAD, irrespective of conventional cardiovascular risk factors.
  • CIMT measurement is a valuable tool for assessing cardiovascular risk in this population.

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