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Experimental renal artery embolization in a combined MR imaging/angiographic unit
Mark W Wilson1, Nicholas Fidelman, Oliver M Weber
1Department of Radiology, University of California, San Francisco, 505 Parnassus Avenue, Room M-361, San Francisco, CA 94143, USA. Mark.Wilson@radiology.ucsf.edu
Journal of Vascular and Interventional Radiology : JVIR
|September 30, 2003
Summary
This study demonstrates that MR imaging can guide arterial embolization with gadolinium-impregnated microspheres in a canine kidney model, showing different deposition patterns based on microsphere size and significantly reducing renal blood flow.
Area of Science:
- Interventional Radiology
- Medical Imaging
- Nephrology
Background:
- Intraarterial catheter manipulation and precise delivery of embolic agents are crucial in interventional radiology.
- Monitoring embolic agent deposition in real-time is essential for successful embolization procedures.
Purpose of the Study:
- To evaluate the use of a combined X-ray angiography and MR imaging (XMR) system for guiding intraarterial catheter manipulation.
- To monitor the in vivo deposition of gadolinium (Gd)-impregnated embolic microspheres in a canine kidney model.
Main Methods:
- Seven dogs underwent renal artery catheterization and embolization with Gd-impregnated microspheres (300-500 and 500-700 µm).
- Renal blood flow was assessed using velocity-encoded cine MR imaging before and after embolization.
- In vivo embolization was guided by fast dynamic T1-weighted MR imaging at one frame per second.
Main Results:
- Successful embolization of renal arteries with Gd-impregnated microspheres in all animals.
- MR imaging revealed distinct deposition patterns: smaller microspheres favored the outer cortex, while larger ones targeted the medulla and inner cortex.
- Significant reduction in renal blood flow was observed post-embolization for both microsphere sizes.
Conclusions:
- MR imaging provides real-time guidance for arterial embolization procedures.
- The study highlights the feasibility of using MR imaging to monitor microsphere deposition and its impact on renal blood flow.