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Related Experiment Videos

Serial bone densitometry during mandibular distraction osteogenesis.

Paolo Campisi1, Reggie C Hamdy, Dominique Lauzier

  • 1The Department of Otolaryngology, Montreal Children's Hospital, McGill University, Montreal, Quebec, Canada.

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|September 30, 2003
PubMed
Summary

Bone mineral density (BMD) in rabbits undergoing mandibular distraction osteogenesis initially decreased but recovered, surpassing control levels by week 7. This suggests BMD measurements can noninvasively assess bone healing during the procedure.

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Regenerative Medicine
  • Biomaterials Science

Background:

  • Distraction osteogenesis is a surgical technique used to lengthen bone segments.
  • Monitoring bone regeneration and mineralization during mandibular distraction is crucial for successful outcomes.
  • Noninvasive methods for assessing bone quality during this process are needed.

Purpose of the Study:

  • To measure serial changes in bone mineral density (BMD) of the mandible during distraction osteogenesis.
  • To evaluate the potential of dual-energy X-ray absorptiometry (DXA) for assessing bone mineralization during mandibular lengthening.

Main Methods:

  • Fourteen skeletally mature male rabbits underwent unilateral mandibular osteodistraction.
  • Bone mineral density (BMD) was measured weekly using dual-energy X-ray absorptiometry (DXA) over 7 weeks.

Related Experiment Videos

  • BMD of the distracted hemi-mandible was compared to the contralateral control hemi-mandible.

    • Main Results:

    • Control hemi-mandibles maintained a stable BMD of 0.5 gm/cm² throughout the study.
    • Distracted hemi-mandibles showed an initial sharp decrease in BMD to 0.35 gm/cm² by week 2.
    • BMD in the distracted segment began to increase from week 3, exceeding control levels by week 7.

    Conclusions:

    • Serial BMD measurements using DXA can track bone mineralization changes during mandibular distraction osteogenesis.
    • The observed BMD pattern indicates an initial phase of bone resorption followed by robust bone formation and maturation.
    • BMD assessment offers a potential noninvasive method to evaluate bone quality and predict healing during distraction osteogenesis.