Related Experiment Video
Updated: Aug 30, 2026

Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Cerebrospinal fluid rhinorrhea: diagnosis and treatment
1Keck School of Medicine of the University of Southern California, Department of Otolaryngology, 1200 N. State Street, Box 795, Los Angeles, CA 90033, USA. dhrice@usc.edu
Abstract:
The diagnosis of cerebrospinal fluid rhinorrhea is usually straightforward. It need not be. The location of the leak is usually clear. It need not be. With modern rigid endoscopes, the repair is usually technically straightforward. It need not be. When a cerebrospinal fluid leak is suggested and the fluid is collectable, testing for beta 2 transferrin will usually settle the issue. The site of the leak is usually obvious. If it is not, but the leak is active, an isoview computed tomography scan will reveal it. Once the leak is established and located, the experienced endoscopic sinus surgeon can generally repair it using the instruments and materials currently available.
Related Concept Videos
Viral Meningitis
Brain Abscess l: Introduction
Cerebrospinal Fluid
CSF Production
CSF is produced mainly in the choroid plexus, a network of capillaries and ependymal cells located within the ventricular system of the brain.
Cryptococcal Meningitis
Bacterial Meningitis I: Introduction
Bacterial Meningitis II: Pathophysiology

