Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of sacral nerve stimulation on autonomic nerve function.

N J Kenefick1, A Emmanuel, R J Nicholls

  • 1The Physiology Unit, St Mark's Hospital, Watford Road, Harrow HA1 3UJ, UK. nickkenefick@hotmail.com

The British Journal of Surgery
|September 30, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gastrointestinal Dysautonomia After Immune Checkpoint Inhibitor Therapy: A Case Series and Systematic Review.

Neurogastroenterology and motility·2025
Same author

Effect of food additives on key bacterial taxa and the mucosa-associated microbiota in Crohn's disease. The ENIGMA study.

Gut microbes·2023
Same author

Adult North Star Network (ANSN): Consensus Guideline For The Standard Of Care Of Adults With Duchenne Muscular Dystrophy.

Journal of neuromuscular diseases·2021
Same author

Letter: tofacitinib in biologic-experienced ulcerative colitis-a single-centre real-world experience in Australia.

Alimentary pharmacology & therapeutics·2021
Same author

Histopathological features for coexistent invasive cancer in large colorectal adenomatous polyps.

BJS open·2021
Same author

Novel strain-level resolution of Crohn's disease mucosa-associated microbiota via an ex vivo combination of microbe culture and metagenomic sequencing.

The ISME journal·2021

Sacral nerve stimulation significantly increases rectal blood flow, indicating an effect on autonomic nerve function. This response is dose-dependent up to 1.0 V and rapidly reversible.

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Urology

Background:

  • Sacral nerve stimulation (SNS) is a proven treatment for bladder and bowel motility disorders.
  • The precise mechanism of action for SNS remains unclear.
  • This study investigates SNS effects on rectal blood flow as an indicator of autonomic nerve function.

Purpose of the Study:

  • To determine the impact of sacral nerve stimulation on rectal blood flow.
  • To assess rectal blood flow as a measure of autonomic nerve function in patients with fecal incontinence.
  • To explore the dose-response relationship of SNS on rectal perfusion.

Main Methods:

  • Sixteen patients with clinically beneficial sacral nerve stimulation for fecal incontinence were studied.
  • Rectal blood flow was measured using laser Doppler flowmetry.

Related Experiment Videos

  • Blood flow was assessed during periods of no stimulation, chronic stimulation, and stepwise voltage increases from 0.1 V to 5 V.

    • Main Results:

    • Chronic sacral nerve stimulation (SNS) significantly increased rectal blood flow compared to no stimulation (P = 0.001).
    • Stepwise increases in stimulation voltage up to 1.0 V resulted in a significant, rapid rise in rectal blood flow (P < 0.001).
    • Higher stimulation levels beyond 1.0 V did not produce further significant increases in blood flow.

    Conclusions:

    • Chronic sacral nerve stimulation demonstrably impacts rectal blood flow and autonomic innervation of the distal bowel.
    • The observed increase in rectal blood flow is dose-dependent, plateauing at approximately 1.0 V.
    • The physiological effects of sacral nerve stimulation on rectal perfusion are rapidly reversible.