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Thoracic neural crest tumors in Beckwith-Wiedemann syndrome

Courtney D Thornburg1, Barry L Shulkin, Valerie P Castle

  • 1Department of Pediatrics/Division of Hematology/Oncology, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA.

Medical and Pediatric Oncology
|September 30, 2003
PubMed
Abstract

No abstract available in PubMed .

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...