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[Correlation between menstruation disorders and insulin resistance]
Andrés González Centeno1, Pedro Nahum Hernández, Rosario Mendoza
1Departamento de Biología de la Reproducción Humana, Dirección de Investigación y Enseñanza, Hospital Juárez de México, S.S.A. México, D.F.
Ginecologia Y Obstetricia De Mexico
|October 1, 2003
Summary
Menstrual abnormalities, particularly amenorrhea, are significantly linked to insulin resistance in women. This condition is also associated with obesity, acanthosis nigricans, and polycystic ovaries, highlighting a complex interplay of metabolic and reproductive health factors.
Area of Science:
- Reproductive Endocrinology
- Metabolic Syndrome
- Clinical Biochemistry
Context:
- Insulin resistance is a key factor in metabolic dysfunction.
- Menstrual cycle abnormalities can indicate underlying endocrine imbalances.
- Understanding these links is crucial for reproductive health management.
Purpose:
- To evaluate the association between various menstrual cycle abnormalities and insulin resistance.
- To identify clinical and biochemical markers associated with insulin resistance in women with irregular menses.
- To explore the prevalence of conditions like polycystic ovary syndrome (PCOS) in relation to menstrual dysfunction and insulin resistance.
Summary:
- This observational study analyzed 50 female patients (18-35 years) with abnormal menses and 28 controls, assessing body mass index (BMI), waist-hip ratio (WHR), acanthosis nigricans, and hormonal profiles.
- Insulin resistance was diagnosed using the HOMA procedure. Amenorrhea showed a statistically significant correlation (P < 0.002) with insulin resistance (78.26% prevalence).
- Obesity, a WHR > 0.85, and polycystic ovaries were more prevalent in patients with insulin resistance, especially those with amenorrhea and opsomenorrhea. Hyperandrogenemia was also noted.
Impact:
- The findings underscore the importance of screening for insulin resistance in women presenting with menstrual irregularities, especially amenorrhea.
- Early detection and management of insulin resistance can help prevent associated complications like PCOS and metabolic disturbances.
- This research contributes to a better understanding of the metabolic underpinnings of reproductive health issues in women.