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[Mini-transplantation for solid tumors].

Sung-Won Kim1, Atsushi Makimoto

  • 1Hematopoietic Stem Cell Transplantation/Immunotherapy Unit, National Cancer Center Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 1, 2003
PubMed
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Reduced-intensity sibling transplantation (RIST) successfully induced complete donor chimerism in patients with solid tumors. This approach shows potential for immunological antitumor effects with manageable toxicities, warranting further investigation.

Area of Science:

  • Immunology
  • Oncology
  • Hematology

Context:

  • Refractory non-renal solid tumors pose significant treatment challenges.
  • Conventional therapies often yield limited efficacy and considerable toxicity.
  • Exploring novel immunotherapeutic strategies is crucial for improving patient outcomes.

Purpose:

  • To evaluate the safety and efficacy of Reduced-Intensity Sibling Transplantation (RIST) in patients with refractory non-renal solid tumors.
  • To assess the primary endpoint of complete donor chimerism.
  • To explore the secondary endpoint of graft-versus-tumor (GVT) effect.

Summary:

  • Twenty-seven patients with refractory solid tumors underwent RIST from family donors.
  • The conditioning regimen included purine analogue and busulfan, with or without antithymocyte globulin.

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  • All patients achieved complete donor chimerism, indicating successful immune reconstitution.

    • Impact:

    • RIST serves as a viable method for delivering immune-competent cells to solid tumor patients.
    • While some patients exhibited a probable GVT effect, further phase II-III trials are needed to confirm efficacy across different tumor types.