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Synthesis of propenamides with anti-malarial activities and 3D-QSAR study
Mao-sheng Cheng1, Dong Yan, Qian-li Wang
1School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China. mscheng@mail.sy.ln.cn
Aim:
To establish 3D QSAR model of propenamides with anti-malarial activities.
Methods:
Chemical synthesis combined with comparative molecular field analysis (CoMFA).
Results:
Generated QSAR models for activities of inhibiting chloroquine resistive malaria (W2) and chloroquine sensitive malaria (D6).
Conclusion:
The activity of anti-W2 depends mostly on steric interaction and the activity of anti-D6 depends on both steric and electrostatic interaction.
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