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Updated: Aug 4, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
Published on: September 14, 2010
Primary pulmonary hypertension, Castleman's disease and human herpesvirus-8
T M Bull1, C D Cool, A E Serls
1Dept of Medicine, Division of Pulmonary and Critical Care Medicine, Pulmonary Hypertension Center, Denver, CO 80262, USA. Todd.Bull@uchsc.edu
Abstract:
Primary pulmonary hypertension (PPH) and Castleman's disease (CD) are rare conditions infrequently encountered in clinical practice. In this paper, two patients diagnosed with both of these diseases are reported. The authors speculate that rather than being a chance occurrence, these conditions are linked by a common angio-proliferative mechanism. Therefore, an association between infection with the human herpesvirus-8 and the diseases of PPH and CD was sought. Evidence of human herpesvirus-8 infection was found in the lung tissue and, specifically, in the plexiform lesions from one of the patients.
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