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Spirometric reference values in a large Middle Eastern population.

M Golshan1, M Nematbakhsh, B Amra

  • 1Dept of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. golshan@med.mui.ac.ir

The European Respiratory Journal
|October 1, 2003
PubMed
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This study developed new spirometry prediction equations for Persians in Iran. These local equations are more accurate for interpreting lung function in Iranian populations compared to existing Western values.

Area of Science:

  • Pulmonary Medicine
  • Medical Statistics
  • Population Health

Background:

  • Ethnic variations in pulmonary function are well-documented.
  • Existing spirometry reference values may not accurately represent diverse ethnic groups.
  • Establishing population-specific equations is crucial for accurate lung function assessment.

Purpose of the Study:

  • To derive and validate prediction equations for spirometry in a large Persian population in Isfahan, Iran.
  • To compare these derived equations with reference values from a White Euro-USA population.
  • To assess the suitability of local versus international reference values for Iranian individuals.

Main Methods:

  • Spirometry measurements were conducted on 4,341 healthy, non-smoking Persians in Isfahan, adhering to American Thoracic Society guidelines.

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  • Multiple regression analysis was used to derive prediction equations from 3,213 subjects.
  • The remaining 1,128 subjects served as a control group to validate the derived equations.

    • Main Results:

    • The derived prediction equations demonstrated good performance for most spirometric parameters.
    • Adult Persians exhibited slightly lower forced vital capacities compared to USA Whites, while children's values were similar.
    • Local reference values were found to be more suitable for interpreting spirometric data in Iranian populations.

    Conclusions:

    • New spirometry prediction equations were successfully derived for the Persian population in Isfahan.
    • These local equations offer improved accuracy for lung function assessment in Iranians compared to international standards.
    • The findings highlight the importance of ethnicity-specific reference values in pulmonary function testing.