Related Experiment Video
Updated: Aug 30, 2026

A Murine Model of Group B Streptococcus Vaginal Colonization
Published on: November 16, 2016
A novel family of fibrinogen-binding proteins in Streptococcus agalactiae
1Department of Microbiology, Swedish University of Agricultural Sciences, P.O. Box 7025, SE-750 07, Uppsala, Sweden. karin.jacobsson@mikrob.sle.se
Abstract:
Streptococcus agalactiae is a contagious pathogen in bovine mastitis. It is also one of the leading causes to neonatal pneumonia, sepsis and meningitis in Europe and North America. Although extracellular bacterial proteins that interact with host structures are putative vaccine components, so far only a few receptins have been identified and characterised from this organism. The aim of the present study was to identify fibrinogen-binding receptins from a shotgun phage display library constructed from the bovine type strain CCUG 4208. A novel extracellular receptin was identified after selecting the library against bovine fibrinogen. This protein is a member of a family of at least three proteins that share the fibrinogen-binding region as well as the N-terminal signal sequence, whereas the intervening region varies in size and has almost no sequence similarity. Proteins of this family are present also in human isolates of S. agalactiae, although binding to human fibrinogen has not been detected.
More Related Videos
08:53Biochemical and Structural Characterization of the Carbohydrate Transport Substrate-binding-protein SP0092
Published on: October 2, 2017
11:32Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria
Published on: February 23, 2014
Related Concept Videos
Cytoskeletal Proteins in Bacteria
Protein Families
Determinants of Bacterial Pathogenicity and Virulence
Fimbriae, Pili, and Axial Filaments
Protein Complexes with Interchangeable Parts
The SCF ubiquitin ligase is a protein complex of five individual proteins. This complex attaches ubiquitin to other target proteins to mark them for degradation. In order to...
Transcytosis of IgG
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...