Related Experiment Video
Updated: Aug 30, 2026

In vitro Measurements of Tracheal Constriction Using Mice
Published on: June 25, 2012
Regulation of beta-adrenergic responses in airway smooth muscle
Stephanie A Shore1, Paul E Moore
1Physiology Program, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA. sshore@hsph.harvard.edu
Abstract:
Decreased responsiveness to beta-adrenergic receptor agonists is a characteristic feature of human asthma. This review summarizes data regarding the impact of chronic beta agonist stimulation, cytokines, prostanoids and other factors on beta-adrenergic responses in human airway smooth muscle, as well as the impact of polymorphisms of the beta(2)-adrenergic receptor on these responses. Effects of beta-agonists on both airway smooth muscle relaxation and gene expression are considered. Understanding the regulation of beta-adrenergic responses in airway smooth muscle cells may prove to be an important step in improving the efficacy of beta-agonists for the treatment of asthma.
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