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Punctal-canalicular stenosis associated with mitomycin-C for corneal epithelial dysplasia
Kathryn Billing1, Arthur Karagiannis, Dinesh Selva
1Department of Ophthalmology, Royal Adelaide Hospital, The University of Adelaide, Adelaide, Australia.
Purpose:
To report a case of punctal-canalicular stenosis after topical mitomycin C use for corneal dysplasia. To the authors' knowledge, this association has not previously been described.
Design:
Observational case report.
Method:
A 62-year-old woman was noted to have a right inferotemporal corneal dysplastic lesion. She received a topical course of mitomycin-C 0.04% four times a day, which subsequently invoked a toxoallergic reaction. One month later, the patient developed right-sided epiphora.
Results:
Probing demonstrated complete stenosis of the right lower canaliculus, 5 mm from the punctum.
Conclusion:
Mitomycin-C use may lead to lacrimal apparatus fibrosis and symptomatic epiphora when inciting a toxoallergic reaction.
