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Rescaled range analysis applied to the study delayed rectifier potassium channel kinetics.

Tong-Han Lan1, Bang-Quan Xu, Hui-Jun Yuan

  • 1Department of Biomedical Engineering, Huazhong University of Science and Technology, Wuhan 430074, PR China. lthan@163.com

Biophysical Chemistry
|October 1, 2003
PubMed
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Ion channel gating exhibits long-term memory, challenging the assumption of memoryless transitions. This antipersistent correlation in channel open and closed times was observed in delayed rectifier K(+) channels.

Area of Science:

  • Biophysics
  • Ion Channel Physiology

Background:

  • Ion channel gating is often modeled as a memoryless process.
  • However, analysis of unitary current events suggests kinetic processes with long lags (antipersistent correlation).

Purpose of the Study:

  • To investigate the kinetic properties of single-channel delayed rectifier K(+) channels.
  • To determine if channel gating exhibits antipersistent correlation.

Main Methods:

  • Patch-voltage clamp technique was employed.
  • Rescaled range (R/S) method and Hurst coefficient calculation were used to analyze channel activity.
  • Activity of single-channel delayed rectifier K(+) channels in rat dorsal root ganglion neurons was studied.

Main Results:

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  • The Hurst coefficient (H) indicated antipersistent correlation in open-dwell and closed-dwell times across tested pipette potentials (V=-30 to -60 mV).
  • Calculated H values ranged from 0.34169 to 0.3954, differing significantly from a simulated Markovian model (H=0.2531 at V=-40 mV).
  • The observed antipersistent correlation did not change with applied pipette potential.

    • Conclusions:

    • Single-channel delayed rectifier K(+) channel gating exhibits long lags, demonstrating antipersistent correlation.
    • This finding contradicts the traditional memoryless gating models.
    • The gating kinetics are independent of the applied pipette potential within the tested range.