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Phospholipase D in cell proliferation and cancer
1The Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10021, USA. foster@genectr.hunter.cuny.edu
Molecular Cancer Research : MCR
|October 1, 2003
Summary
Phospholipase D (PLD) regulates key cell functions like transport and division. Abnormal PLD activity is linked to human cancers, affecting proliferation, survival, and tumor growth.
Area of Science:
- Biochemistry
- Cell Biology
- Oncology
Background:
- Phospholipase D (PLD) catalyzes phosphatidylcholine (PC) hydrolysis to phosphatidic acid (PA) and choline.
- PLD activation is linked to essential cellular processes including vesicle transport, endocytosis, exocytosis, cell migration, and mitosis.
- Dysregulation of these cellular processes is implicated in human tumor development.
Purpose of the Study:
- To review the evidence implicating Phospholipase D (PLD) in cancer.
- To summarize PLD's role in cell proliferation, survival signaling, cell transformation, and tumor progression.
Main Methods:
- Literature review of studies on Phospholipase D (PLD) in cancer.
- Analysis of evidence linking PLD expression and activity to human tumors.
Main Results:
- Abnormalities in PLD expression and activity are observed in numerous human cancers.
- PLD acts as a critical regulator of cell proliferation and survival signaling.
- PLD is implicated in cell transformation and the progression of tumors.
Conclusions:
- Phospholipase D (PLD) plays a significant role in the development and progression of human cancers.
- Targeting PLD may offer therapeutic strategies for cancer treatment.