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The role of soluble cell adhesion molecules in patients with suspected deep vein thrombosis

Robert A Bucek1, Markus Reiter, Peter Quehenberger

  • 1University Clinic of Internal Medicine II, General Hospital, Vienna, Austria. robert.bucek@akh-wien.ac.at

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
|October 1, 2003
PubMed

Insights

Soluble cell adhesion molecules (sCAMs) were evaluated for diagnosing deep venous thrombosis (DVT). Researchers found no significant differences in sCAM levels between DVT patients and controls, indicating they are not useful diagnostic markers for DVT.

Area of Science:

  • Vascular Biology
  • Hematology
  • Diagnostic Medicine

Background:

  • Endothelial, platelet, and leukocyte activation are implicated in deep venous thrombosis (DVT) etiology.
  • This activation leads to the release of soluble cell adhesion molecules (sCAMs).

Purpose of the Study:

  • To assess the diagnostic value of four major sCAMs in patients with suspected DVT.
  • To determine if sCAM levels correlate with DVT presence, extension, or symptom duration.

Main Methods:

  • Measured levels of soluble intracellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble E-selectin, and soluble P-selectin.
  • Compared sCAM levels in 69 patients with suspected DVT (37 confirmed) against controls.
  • Used Duplex sonography or ascending venography for DVT diagnosis.

Main Results:

  • No significant differences in mean levels of sVCAM-1, sICAM-1, soluble E-selectin, or soluble P-selectin were found between DVT patients and controls (P > 0.05).
  • No significant correlation was observed between thrombus extension or symptom duration and the measured sCAM levels (P > 0.05).

Conclusions:

  • The concentration of the four major sCAMs assessed does not differ significantly between patients with and without DVT.
  • Assessment of these sCAMs does not provide additional useful information for the diagnostic process of DVT.

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