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Malignant fibrous histiocytoma: past, present, and future

A E Rosenberg1

  • 1James Homer Wright Laboratories, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

Skeletal Radiology
|October 1, 2003
PubMed
Abstract

No abstract available in PubMed .

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

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