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Related Experiment Videos

Diabetes Mellitus: Does it Affect Bone?

A V Schwartz1

  • 1Department of Epidemiology and Biostatistics, University of California San Francisco, CA, USA. aschwartz@psg.ucsf.edu

Calcified Tissue International
|October 1, 2003
PubMed
Summary
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Diabetes increases fracture risk in older adults, particularly in type 2 diabetes. This paradox, despite higher bone mineral density, may stem from falls and poorer bone quality due to diabetes complications.

Area of Science:

  • Gerontology
  • Endocrinology
  • Orthopedics

Background:

  • Diabetes and fractures are prevalent in older adults.
  • Diabetes is linked to increased fracture risk, especially hip, humerus, and foot fractures.
  • The relationship between diabetes, bone strength, and fracture risk is debated.

Purpose of the Study:

  • To explore the complex relationship between diabetes and fracture risk in older adults.
  • To understand the mechanisms by which diabetes impacts bone health.
  • To identify factors contributing to the increased fracture risk in diabetic individuals.

Main Methods:

  • Review of recent cohort studies and observational data.
  • Analysis of animal models investigating bone strength in diabetes.

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  • Examination of various pathways through which diabetes affects bone metabolism.

    • Main Results:

    • Type 1 diabetes shows modest bone mineral density reduction.
    • Type 2 diabetes often presents with elevated bone mineral density but higher fracture risk.
    • Potential explanations include increased falls and compromised bone quality.
    • Multiple diabetes-related pathways (obesity, advanced glycation end products, inflammation) impact bone.

    Conclusions:

    • The paradox of higher bone mineral density and increased fracture risk in type 2 diabetes requires further investigation.
    • Understanding diabetes' effects on bone is crucial for effective fracture prevention strategies.
    • Targeting diabetes metabolism and treatment effects on bone could improve outcomes for older diabetic adults.