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The contribution of prothrombotic disorders to peri- and neonatal ischemic stroke

Meredith R Golomb1

  • 1Department of Neurology, Riley Hospital for Children, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. mgolomb@iupui.edu

Seminars in Thrombosis and Hemostasis
|October 1, 2003
PubMed

Insights

Prothrombotic disorders are key causes of perinatal stroke and thrombosis, potentially leading to lifelong disability. This review covers maternal and fetal hematological factors, and other contributors, to inform prevention and treatment strategies.

Area of Science:

  • Perinatal medicine
  • Hematology
  • Neonatology

Background:

  • Prothrombotic disorders are significant contributors to perinatal arterial ischemic stroke and sinovenous thrombosis.
  • These conditions can result in lifelong disabilities for affected individuals.
  • Understanding the unique hematological landscape of the perinatal period is crucial.

Purpose of the Study:

  • To review hematological issues unique to the perinatal period.
  • To discuss maternal and fetal prothrombotic disorders and their role in stroke.
  • To explore other maternal and neonatal risk factors for perinatal stroke.

Main Methods:

  • Review of hematological changes during gestation and postpartum.
  • Analysis of the placenta's role in maternal-fetal circulation.
  • Discussion of various maternal and neonatal risk factors.

Main Results:

  • The placenta is a critical interface influencing fetal and maternal coagulation.
  • Maternal coagulation undergoes significant physiological changes during and after pregnancy.
  • Prothrombotic conditions in mother or fetus are strongly associated with stroke risk.

Conclusions:

  • Hematological factors, particularly prothrombotic disorders, are central to perinatal stroke etiology.
  • Identifying and managing these disorders is vital for preventing adverse outcomes.
  • Comprehensive assessment of maternal and neonatal risk factors aids in stroke management.

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