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Related Concept Videos

  • Physical Sciences
  • Condensed Matter Physics
  • Surface Properties Of Condensed Matter
  • The Chemokine Ccl21 Modulates Lymphocyte Recruitment And Fibrosis In Chronic Hepatitis C.
  • Physical Sciences
  • Condensed Matter Physics
  • Surface Properties Of Condensed Matter
  • The Chemokine Ccl21 Modulates Lymphocyte Recruitment And Fibrosis In Chronic Hepatitis C.

    • Related Experiment Videos

    The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.

    Andrea Bonacchi1, Ilaria Petrai, Raffaella M S Defranco

    • 1Dipartimento di Medicina Interna, University of Florence, Florence, Italy.

    Gastroenterology
    |October 1, 2003

    View abstract on PubMed

    Summary
    This summary is machine-generated.

    In chronic hepatitis C, CCL21 and CCR7 chemokines are upregulated, attracting T lymphocytes and potentially promoting liver fibrosis through hepatic stellate cell activation.

    Related Experiment Videos

    Area of Science:

    • Immunology
    • Hepatology
    • Cell Biology

    Background:

    • Chemokines CCL19 and CCL21 bind to CCR7, crucial for lymphoid tissue organization and inflammation.
    • CCR7 is expressed during chronic inflammation, prompting investigation in chronic hepatitis C.

    Purpose of the Study:

    • To investigate the expression of CCL21 and CCR7 in chronic hepatitis C.
    • To determine the effects of CCL21 on hepatic stellate cells (HSCs).

    Main Methods:

    • CCL21 expression analyzed via in situ hybridization and immunohistochemistry.
    • CCR7 on T cells assessed by flow cytometry.
    • Human HSCs cultured and studied in activated phenotype.

    Main Results:

    • CCL21 and CCR7 expression were elevated in chronic hepatitis C patients.
    • CCL21 localized near T lymphocytes and dendritic cells in portal tracts.
    • HSCs expressed functional CCR7, with CCL21 triggering pro-inflammatory pathways and HSC activation.

    Conclusions:

    • CCL21/CCR7 axis in chronic hepatitis C contributes to T lymphocyte recruitment and inflammatory tissue organization.
    • Activated CCR7 on HSCs may promote liver fibrogenesis in inflamed areas.