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lunatic fringe regulates Delta-Notch induction of hypochord in zebrafish

Bruce Appel1, Paul Marasco, Laura E McClung

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235-1634, USA. b.appel@vanderbilt.edu

Developmental Dynamics : an Official Publication of the American Association of Anatomists
|October 1, 2003
PubMed

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Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...