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Updated: Jul 28, 2026

Delayed Intramyocardial Delivery of Stem Cells after Ischemia Reperfusion Injury in a Murine Model
Published on: September 3, 2020
[Modification of immune response after polytrauma and cardiopulmonary bypass by hematopoietic growth factors]
S Flohé1, J Börgermann, E Kreutzfelder
1Klinische Forschergruppe Schock und MOV, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen.
Abstract:
Cardiac surgery and polytrauma result in an impaired immune response as it can be demonstrated by a reduced endotoxin-stimulated TNF alpha production of whole blood cultures ex vivo. The immune-stimulating hematopoetic growth factor GM-CSF is in vitro capable to antagonize the suppressed immune function after trauma and cardiac surgery and, therefore, GM-CSF represents a potential therapeutic for immune suppressed states.
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