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Microfluidic Platform for Measuring Neutrophil Chemotaxis from Unprocessed Whole Blood
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[What is the function of neutrophilic granulocytes in microcirculatory disorders in free tissue transfer?]

F W Peter1, J H Barker, P M Vogt

  • 1Klinik für Plastische Chirurgie, Handchirurgie und Schwerbrandverletzte, Ruhr Universität, BG-Kliniken Bergmannsheil, Bochum.

Langenbecks Archiv Fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft Fur Chirurgie. Kongress
|October 2, 2003
PubMed

In a free flap model capillary perfusion in the downstream tissue, i.e. the flap is significantly decreased after one hour of ischemia. This decrease occurs even though circulating PMN's have been depleted and are not available to mediate this phenomenon. It is suggested that PMN's do not mediate the mechanism responsible for reduced capillary perfusion and possible microvascular failure.

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