Membrane and cytoskeleton dynamics during axonal elongation and stabilization

Proper nervous activities are gradually developing events. Reflecting this, embryonic neurons start differentiation by sprouting multiple extensions, neurites, which do not bear clear axonal or dendritic structural and molecular characteristics. Later in development one of these multiple neurites elongates further, generating a morphologically polarized neuron with a single long axon and many short dendrites. Still, despite such morphological differences these processes can switch destiny, further reflecting their immaturity. Final and irreversible axonal and dendritic commitment occurs after both axons and dendrites have elongated considerably. Recent evidence suggests that the transition from axonal immaturity to maturity reflects changes in the mechanisms used by neurons to control the precise membrane and cytoskeleton polarization. This chapter provides an overview of how these mechanisms contribute to the formation of an axon.