Related Experiment Video
Updated: Jul 18, 2026

13:37
Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
A stereodivergent approach to chiral nonracemic N-protected alpha,alpha-dialkylated amino acids
Claude Spino1, Cédrickx Godbout, Cédrickx Gobdout
1Département de Chimie, Université de Sherbrooke, 2500 Boul. Université, Sherbrooke, QC, Canada, J1K 2R1. Claude.Spino@USherbrooke.ca
Journal of the American Chemical Society
|October 2, 2003
Abstract:
Menthyl carboxaldehyde is used as a chiral auxiliary to make quaternary amino acids of either configuration via a stereodivergent approach that includes an SN2' displacement by a cuprate reagent and a Curtius rearrangement as key steps.

