Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dapsone-induced acute pancreatitis.

Shivkumar H Jha1, Jyothi A Reddy, Jatin K Dave

  • 1Department of Pharmacology and Psychiatry, School of Medicine, Boston University, Boston, MA 02118-2526, USA. jha@bu.edu

The Annals of Pharmacotherapy
|October 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Innovation in care for individuals with cognitive impairment: Can reimbursement policy spread best practices?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2017
Same author

The risk of dementia with increased body mass index.

Age and ageing·2006
Same author

Ethnicity and diabetic heart disease.

Endocrinology and metabolism clinics of North America·2006
Same author

Effects of morphine on brain-stimulation reward thresholds in young and aged rats.

Pharmacology, biochemistry, and behavior·2004
Same author

Increased sensitization to morphine-induced oral stereotypy in aged rats.

Pharmacology, biochemistry, and behavior·2004
Same author

Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells.

Gene·2003
Same journal

Prolonged Response to Nivolumab in Metastatic Vulvar Carcinoma: Should Immunotherapy be Continued and for How Long? A Debatable Issue!

The Annals of pharmacotherapy·2026
Same journal

Stability of Ceftazidime-Avibactam: Changes in Regulatory Information and Implications for Preparation.

The Annals of pharmacotherapy·2026
Same journal

Impact of Early Dose Adjustment of Piperacillin/Tazobactam on Mortality in Critically Ill Patients With Acute Kidney Injury: A Retrospective Multicenter Cohort Study.

The Annals of pharmacotherapy·2026
Same journal

Severe Phototoxic Skin Reaction Associated With Vandetanib: Implications for Pharmaceutical Care.

The Annals of pharmacotherapy·2026
Same journal

Efficacy and Safety of Oral PCSK9 Inhibitors in Adults With Hypercholesterolemia: An Updated Systematic Review and Meta-Analysis of RCTs.

The Annals of pharmacotherapy·2026
Same journal

RSVpreF: A Vaccine for the Respiratory Syncytial Virus.

The Annals of pharmacotherapy·2026
See all related articles

Dapsone, a medication used for various skin conditions and infections, can cause acute pancreatitis. This adverse effect, though uncommon, requires clinical suspicion, especially in patients without other risk factors.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Dermatology

Background:

  • Dapsone is a widely used antimicrobial and anti-inflammatory agent.
  • Its therapeutic applications extend beyond leprosy and dermatitis herpetiformis to include prophylaxis for Pneumocystis carinii pneumonia (PCP), malaria, and other conditions.
  • The potential for adverse drug reactions necessitates ongoing vigilance and reporting.

Observation:

  • A case report details an 87-year-old male who developed recurrent acute pancreatitis after initiating dapsone for dermatitis herpetiformis.
  • The patient experienced severe abdominal pain, elevated amylase, and lipase levels, with symptom resolution upon dapsone discontinuation and recurrence upon reintroduction.
  • Exhaustive laboratory workup excluded other common causes of pancreatitis.

Findings:

Related Experiment Videos

  • Dapsone was identified as the probable causative agent of acute pancreatitis based on the Naranjo probability scale.
  • A literature review revealed only one prior reported case of dapsone-associated pancreatitis.
  • This case highlights the potential for dapsone to induce pancreatitis, an uncommon but serious adverse effect.

Implications:

  • Clinicians should consider dapsone as a potential cause of pancreatitis in patients presenting with unexplained symptoms, particularly those without typical risk factors.
  • Increased awareness of dapsone-induced pancreatitis is crucial for timely diagnosis and management.
  • Further research and case reporting are essential to fully understand the incidence and mechanisms of drug-induced pancreatitis.