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Allogeneic immune replacement as cancer immunotherapy

Sakti Chakrabarti1, Richard Childs

  • 1National Heart, Lung, and Blood Institute, Hematology branch, 9000 Rockville Pike, Bethesda, Maryland 20892, USA.

Expert Opinion on Biological Therapy
|October 2, 2003
PubMed

The graft-versus-leukaemia (GVL) reaction that occurs after allogeneic haematopoietic cell transplantation (HCT) can cure patients with a variety of haematological malignancies. A heightened appreciation of the GVL effect has resulted in the development of reduced intensity transplant approaches, where antitumour effects occur predominantly as a consequence of the transplanted donor immune system. The recent success of these transplants in patients with acute and chronic leukaemias has led to trials investigating for graft-versus-tumour (GVT) effects in patients with treatment-refractory metastatic solid tumours. This review discusses evidence that immune replacement following allogeneic HCT is a potent form of cancer immunotherapy for patients with haematological and non-haematological malignancies.

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