Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progesterone antagonists and progesterone receptor modulators.

Irving M Spitz1

  • 1Institute of Hormone Research, Shaare Zedek Medical Center, PO Box 3235, Jerusalem, 91031, Israel. spitz@rockefeller.edu

Expert Opinion on Investigational Drugs
|October 2, 2003
PubMed
Summary

Progesterone antagonists, like mifepristone, offer diverse female healthcare applications beyond pregnancy termination. These compounds show promise for contraception, endometriosis, uterine fibroids, and gene expression regulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mifepristone: Reflections on its Early Clinical Development for Medical Abortion.

Rambam Maimonides medical journal·2026
Same author

Three Giants in the Cradle of Reproductive Medicine; Reproduction Theories of the Seventeenth Century as Discerned by Pregnancy Portraiture in the Oeuvre of Jan Vermeer.

Rambam Maimonides medical journal·2016
Same author

Mifepristone: where do we come from and where are we going? Clinical development over a quarter of a century.

Contraception·2010
Same author

Free alpha-subunit is the most sensitive marker of gonadotropin recovery after treatment of central precocious puberty with the histrelin implant.

The Journal of clinical endocrinology and metabolism·2010
Same author

Relationships between FSH, inhibin B, anti-Mullerian hormone, and testosterone during long-term treatment with the GnRH-agonist histrelin in patients with prostate cancer.

European journal of endocrinology·2009
Same author

Clinical utility of progesterone receptor modulators and their effect on the endometrium.

Current opinion in obstetrics & gynecology·2009

Area of Science:

  • Reproductive endocrinology
  • Pharmacology
  • Molecular biology

Background:

  • The antiprogestin mifepristone (RU 486) and related compounds modulate progesterone receptor activity.
  • These agents have applications beyond pregnancy termination in female healthcare.

Purpose of the Study:

  • To explore the diverse applications of progesterone antagonists and receptor modulators.
  • To highlight their utility in emergency contraception, gynecological conditions, and gene regulation.

Main Methods:

  • Review of existing literature on progesterone antagonists and modulators.
  • Analysis of their pharmacological effects on the reproductive system and gene expression.

Main Results:

  • Mifepristone serves as an effective emergency contraceptive.

Related Experiment Videos

  • Progesterone antagonists demonstrate antiproliferative effects on the endometrium, aiding in endometriosis and uterine myoma treatment without adverse effects on bone density.
  • These compounds possess contraceptive potential by interfering with follicular development and ovulation.
  • They are utilized in the GeneSwitch system for controlled gene expression.

    • Conclusions:

    • Progesterone antagonists and modulators represent a versatile class of drugs with significant therapeutic potential in female healthcare.
    • Their applications range from contraception and gynecological disorder management to advanced molecular biology techniques.