Related Experiment Video
Updated: Aug 30, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Variability of treatment duration for bacteraemia in the critically ill: a multinational survey
Alberto Corona1, Guido Bertolini, Anna Maria Ricotta
1GiViTI Coordinating Centre, Istituto di Ricerche Farmacologiche Mario Negri, Centro di Ricerche Cliniche per le Malattie Rare Aldo e Cele Daccò, Ranica (BG), Italy.
Objectives:
No definitive evidence is available to inform 'best' antibiotic practice for treating bacteraemia in the critically ill patient, either in terms of duration of therapy, or the use of mono- versus combination therapy. We therefore undertook a large-scale international survey to assess the variability of current practice.
Methods:
A questionnaire was sent to membership lists of national and international intensive care societies.
Results:
Responses from 254 intensive care units in 34 countries revealed a wide variation in antibiotic strategy for all types of bacteraemia, ranging from short course (
Conclusions:
The wide variability in antibiotic prescribing patterns suggests an urgent need to produce high-quality evidence to identify optimal antibiotic prescribing policies for bacteraemia in the critically ill patient.
Related Concept Videos
Acute Pyelonephritis II: Diagnostic Studies and Management
Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration
Estimation of k and VD of Aminoglycosides
Urine Studies II: Urine Culture and Sensitivity Test
Clinical Significance of Antibiotic Resistance