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Updated: Aug 13, 2026

Assessment of Oxidative Damage in the Primary Mouse Ocular Surface Cells/Stem Cells in Response to Ultraviolet-C (UV-C) Damage
Published on: February 15, 2020
Generation of reactive oxygen species from Hinokitiol under near-UV irradiation
Hitoshi Shibata1, Takayuki Nagamine, Yong Wang
1Department of Life Science and Biotechnology, Faculty of Life and Environmental Science, Shimane University, Matsue, Japan. shibata@life.shimane-u.ac.jp
Abstract:
Near-UV irradiation caused the decomposition of hinokitiol in an aqueous solution. During the photochemical reaction, the distinct electron spin resonance signal characteristic of the adduct of 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) with the hydroxyl radical was accompanied by small signals corresponding to the adduct of DMPO with the superoxide anion radical. More than 95% of Escherichia coli cells were killed by the incubation with hinokitiol under near-UV irradiation by BLB fluorescent lamps. These results indicated the generation of reactive oxygen species during photochemical reaction of hinokitiol under near-UV irradiation.
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