Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Integrated nanoliter systems.

Jong Wook Hong1, Stephen R Quake

  • 1Department of Applied Physics, California Institute of Technology, MC 128-95, Pasadena, California 91125, USA.

Nature Biotechnology
|October 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reciprocal repulsions enforce heterotypic dendrite segregation in an olfactory circuit.

bioRxiv : the preprint server for biology·2026
Same author

Engulfment by brain macrophages in a short-lived vertebrate.

bioRxiv : the preprint server for biology·2026
Same author

TranscriptFormer: A generative cell atlas across 1.5 billion years of evolution.

Science (New York, N.Y.)·2026
Same author

Template-assisted assembly of structurally diverse plasmonic nanoparticle chains.

Nanoscale·2026
Same author

Cell-free RNA reveals host and microbial correlates of broadly neutralizing antibody development against HIV.

PLoS pathogens·2026
Same author

Non-invasive profiling of exosomal miRNA and protein biomarkers from vaginal discharge for the early detection of preterm labor.

Journal of nanobiotechnology·2026
Same journal

Unlocking the chemical potential of filamentous fungi using prime editing.

Nature biotechnology·2026
Same journal

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells.

Nature biotechnology·2026
Same journal

Prime editing for precise genome engineering and modulation of fungal metabolism.

Nature biotechnology·2026
Same journal

Retargeted serine integrases for one-step, precise integration of large DNA sequences in human cells.

Nature biotechnology·2026
Same journal

A retargeted recombinase for precise insertion of large DNA.

Nature biotechnology·2026
Same journal

Experiment-guided AlphaFold3 resolves measurement-consistent protein ensembles.

Nature biotechnology·2026
See all related articles

Microfluidic chips are advancing genomic and proteomic research by enabling high-throughput processing of tiny liquid volumes. New methods like electrokinetic manipulation and mechanical valves offer greater integration and parallelization for these lab-on-a-chip systems.

Area of Science:

  • Biotechnology
  • Genomics
  • Proteomics

Background:

  • Microfluidic chip platforms are increasingly important for manipulating nanoliter liquid volumes in research.
  • Current challenges include the need for high-throughput processing, miniaturization, and parallelization.

Purpose of the Study:

  • To review recent advances in microfluidic technologies for genomic and proteomic applications.
  • To highlight strategies addressing the demand for high-throughput and parallel processing.

Main Methods:

  • Electrokinetic manipulation techniques.
  • Vesicle encapsulation strategies.
  • Mechanical valve systems for liquid handling.

Main Results:

  • Significant progress has been made in developing microfluidic approaches for small-volume liquid handling.

Related Experiment Videos

  • New strategies offer enhanced integration density and platform complexity.

    • Conclusions:

    • Microfluidic platforms are becoming viable alternatives to traditional robotic systems in research.
    • These technologies promise to revolutionize high-throughput genomic and proteomic analyses.