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Small-scale systems for in vivo drug delivery
David A LaVan1, Terry McGuire, Robert Langer
1Department of Mechanical Engineering, Yale University, New Haven, Connecticut 06520-8284, USA.
Nature Biotechnology
|October 2, 2003
Summary
Micro- and nanosystems offer innovative drug delivery methods, including smart materials and on-demand activation. Challenges remain in balancing device scale with drug dosage and ensuring safety and efficacy for clinical use.
Area of Science:
- Biomedical Engineering
- Materials Science
- Nanotechnology
Background:
- Micro- and nanosystems are revolutionizing drug administration.
- Diverse new materials and methods are emerging for enhanced drug delivery.
Purpose of the Study:
- To review recent advancements in micro- and nanosystems for drug administration.
- To highlight novel approaches and identify current challenges in the field.
Main Methods:
- Exploration of on-demand activation of molecular interactions.
- Development of novel diffusion-controlled delivery devices.
- Design of nanostructured smart surfaces and materials.
- Integration of drug delivery with sensors and implants.
- Utilizing micro- and nanotechnologies for targeted delivery and immune response modulation.
Main Results:
- Emergence of innovative drug delivery strategies.
- Potential for precise control over drug release.
- Prospects for personalized medicine through integrated systems.
Conclusions:
- Micro- and nanotechnologies are transforming drug administration.
- Key challenges include device scalability, drug quantity, sensor stability, and rigorous safety/efficacy evaluation.
- Continued research is crucial for clinical translation.