Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CADASIL: new cases and new questions.

J Rafalowska1, A Fidziańska, D Dziewulska

  • 1Department of Neuropathology, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106, Warsaw, Poland. ddziewul@amwaw.edu.pl

Acta Neuropathologica
|October 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relationship between chicken proventricular necrosis virus prevalence and transmissible viral proventriculitis in broiler chickens in Poland.

Polish journal of veterinary sciences·2021
Same author

Arginine and tetrahydrobiopterin supplementation in rats with salt-induced blood pressure increase: minor hypotensive effect but improvement of renal haemodynamics.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2019
Same author

An evaluation of the impact of aloe vera and licorice extracts on the course of experimental pigeon paramyxovirus type 1 infection in pigeons.

Poultry science·2017
Same author

Differentiation of infectious bronchitis virus vaccine strains Ma5 and 4/91 by TaqMan real-time PCR.

Polish journal of veterinary sciences·2017
Same author

Changing phenotypic expression in a patient with a mitochondrial encephalopathy due to 13042G>A de novo mutation--a 5 year follow up.

Metabolic brain disease·2015
Same author

The development of cerebral amyloid angiopathy in cerebral vessels. A review with illustrations based upon own investigated post mortem cases.

Polish journal of pathology : official journal of the Polish Society of Pathologists·2013
Same journal

CTE-type tau filaments in Alzheimer's disease with co-morbid LATE-NC.

Acta neuropathologica·2026
Same journal

Mutation-specific neuropathologic signatures in MAPT-associated frontotemporal lobar degeneration.

Acta neuropathologica·2026
Same journal

Molecular changes during AT/RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes.

Acta neuropathologica·2026
Same journal

Prion-like transmission and propagation of human β-amyloid to the bank vole rodent model.

Acta neuropathologica·2026
Same journal

Inhibition of tRNA fragments dysregulated in human mTLE exacerbates pathology and seizure activity.

Acta neuropathologica·2026
Same journal

VMA21 deficiency leads to autophagic dysregulation and altered vesicle trafficking in X-linked myopathy with excessive autophagy.

Acta neuropathologica·2026
See all related articles

This study details cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) in two Polish families. It reveals inflammatory changes and granular osmophilic material deposits, raising questions about systemic inflammation and capillary involvement in this genetic vascular disorder.

Area of Science:

  • Neurology
  • Genetics
  • Pathology

Background:

  • Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukencephalopathy (CADASIL) is a rare genetic vascular disorder.
  • Understanding its pathological mechanisms is crucial for diagnosis and treatment.

Purpose of the Study:

  • To describe the first two unrelated Polish families diagnosed with CADASIL.
  • To investigate the morphological and ultrastructural changes associated with CADASIL.

Main Methods:

  • Light microscopy was used to examine vascular changes, noting panarteritis nodosa-like features and basophilic granular material.
  • Electron microscopy identified granular osmophilic material (GOM) deposits in vessel walls, including capillaries.

Main Results:

Related Experiment Videos

  • Two distinct pathological patterns were observed: inflammatory changes resembling panarteritis nodosa and characteristic CADASIL features.
  • Granular osmophilic material (GOM) was found in the walls of arteries, veins, and capillaries.

Conclusions:

  • The presence of systemic inflammatory features in a genetically determined vascular disorder warrants further investigation.
  • The occurrence of GOM deposits in capillary walls, which lack smooth muscle cells, requires further study to understand CADASIL pathogenesis.